What is RHPCG?
Hippo signaling pathway is a highly conserved pathway, which is consisted of a group of kinases. Dysregulation of Hippo signaling pathway is involved in the initiation and progression of cancer, such as breast cancer, lung cancer and so on. RHPCG serves as a valuable resource for understanding the roles of Hippo signaling pathway in carcinogenesis. The features of RHPCG contain: (i) the landscape of Hippo gene alterations at multiple omics level; (ii) quick search Hippo regulatory motifs by mRNA, lncRNA, circRNA or miRNA; and (iii) all the Hippo related motifs can be visualized as network and be downloaded freely.
In general, Hippo signaling pathway was divided into three parts: (1) upstream regulators (NF2, WWC1, FRMD6), (2) core kinase molecules (STK3/4, LATS1/2, SAV1, MOB1) and (3) major co-activators (YAP1/TAZ). The membrane receptor transmits extracellular inhibitory signals to upstream factors and leads to a series of kinase phosphorylation reactions. The outcome of Hippo pathway is the cytoplasmic retention and eventually degradation of the coactivators YAP1 (Yes associated protein 1) and TAZ (transcriptional coactivator with PDZ-binding motif). When the Hippo signaling pathway is closed, the co-activators YAP1/TAZ go into the nucleus and bind with the TEA domain DNA-binding family of transcription factors (TEADs) to start the downstream transcription process, which induce EMT (Epithelial-Mesenchymal Transition) and cell proliferation. And some other genes of the pathway also involving in the reaction axis, such as RASSFs, AMOTs and so on. Based on Hippo signaling structure and mechanism, we manually defined 21 “core genes”, which play essential roles in Hippo signaling pathway .
Predicting effective microRNA target sites in mammalian mRNAs.
Elife. 2015;4
miRBase: microRNA sequences, targets and gene nomenclature.
Nucleic Acids Res,2006;34(Database Issue):D140-D144
miRTarBase: a database curates experimentally validated microRNA-target interaction.
Nucleic Acids Res,2011;39(Database Issue):D163-9
TRANSFAC: transcriptional regulation, from patterns to profiles.
Nucleic Acids Res,2003;31:374-8
The microRNA.org resource: targets and expression.
Nucleic Acids Res,2008;36(Database Issue):D149-53
circBase: a database for circular RNAs.
RNA,2014;1666-70
miRcode: a map of putative microRNA target sites in the long non-coding transciptome.
Bioinformatics 2012;28(15):2062-3
starBase v2.0: decoding miRNA-ceRNA, miRNA-ncRNA and protein-RNA interaction networks from large-scale CLIP-Seq data.
Nucleic Acids Res,2014;42(Database Issue):D92-7
Molecular signatures database(MSigDB) 3.0.
Bioinformatics,2011;27(12):1739-40
ChIPBase: a database for decoding the thanscriptional regulation of long non-coding RNA and microRNA genes from ChIP-Seq data.
Nucleic Acids Res,2013;41(Database Issue):D177-87
TransmiR: a transcription factor-microRNA regulation database.
Nucleic Acids Res,2010;38(Database Issue):D119-22
RHPCG 1.0
Contact us: guyunyan@ems.hrbmu.edu.cn
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