Welcome to Fibroblast Atlas !
The application of single-cell RNA-seq (scRNA-seq) technology has revealed that fibroblasts are highly heterogeneous in terms of their phenotype, origin and function. Understanding the heterogeneity of fibroblasts depends on defining the complexity of cell subtypes, their origin, distribution, and interactions with cells in the tumor microenvironment. Multiple single-cell studies on the same or different tissues identified similar fibroblast subtypes but assigned them different names. However, it is unclear whether this phenomenon can be extended to other cancer types, and these shared and specific features of cancer-associated fibroblast subtypes remain unknown. Here, we curated a total of 73 single-cell studies across 10 tissues and developed a high-resolution classification of fibroblasts, named Fibroblast Atlas. The current version of Fibroblast Atlas documents 18 fibroblast subtypes composed of 249,156 fibroblasts. Moreover, Fibroblast Atlas also provides the distribution, comparisons, cell interactions, and prognosis of fibroblast subtypes in human cancer. Users can explore and browse for fibroblast subtypes and corresponding information of interest.
Please cite
Fibroblast atlas: shared and tissue-specific cell types across tissues.
Copyright © 2023. College of Bioinformatics Science and Technology,Harbin Medical University, China.
Fibroblast subtypes & Functional enrichment
Fibroblast clustering
Marker genes
Copyright © 2023. College of Bioinformatics Science and Technology,Harbin Medical University, China.
Distribution of fibroblast subtypes
Venn diagram
Venn diagram
Copyright © 2023. College of Bioinformatics Science and Technology,Harbin Medical University, China.
Consistency of fibroblast atlas and previous fibroblast subtypes
Comparison of fibroblast subtypes
Copyright © 2023. College of Bioinformatics Science and Technology,Harbin Medical University, China.
Cell interaction
The receptor-ligand interactions
The receptor-ligand interactions
Copyright © 2023. College of Bioinformatics Science and Technology,Harbin Medical University, China.
Overall interaction strength
Overall interaction strength
Copyright © 2023. College of Bioinformatics Science and Technology,Harbin Medical University, China.
Survival analysis
Copyright © 2023. College of Bioinformatics Science and Technology,Harbin Medical University, China.
Age distribution of fibroblast subtypes
Cell senescence of fibroblast subtypes
Associations between age and cell senescence
Correlation analysis between age and cell senescence
Copyright © 2023. College of Bioinformatics Science and Technology,Harbin Medical University, China.
I. Details of single-cell datasets
II. Details of single-cell samples
Copyright © 2023. College of Bioinformatics Science and Technology,Harbin Medical University, China.
Copyright © 2023. College of Bioinformatics Science and Technology,Harbin Medical University, China.
Contact
If you have any questions or find any problems, please feel free to contact us.
Each question you ask, each suggestion you make, contributes to our progress.
Yunyan Gu: guyunyan@ems.hrbmu.edu.cn
Kaidong Liu: liukaidong@hrbmu.edu.cn
Copyright © 2023. College of Bioinformatics Science and Technology,Harbin Medical University, China.