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SynlethDB: synthetic lethality database toward discovery of selective and sensitive anticancer drug targets.
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Nucleic Acids Res, 2016-1
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19952
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735 KB
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Genetic interaction mapping in mammalian cells using CRISPR interference.
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Nat Methods, 2017-6
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312
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14 KB
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Combinatorial CRISPR-Cas9 screens for de novo mapping of genetic interactions.
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Nat Methods. , 2017-6
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193
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8 KB
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Synergistic drug combinations for cancer identified in a CRISPR screen for pairwise genetic interactions.
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Nat Biotechnol, 2017-5
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38
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2 KB
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Therapeutic relevance of the protein phosphatase 2A in cancer.
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Oncotarget, 2016-9
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464
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19 KB
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A Network of Conserved Synthetic Lethal Interactions for Exploration of Precision Cancer Therapy.
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Mol Cell, 2016-8
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5556
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185 KB
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Ranking novel cancer driving synthetic lethal gene pairs using TCGA data.
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Oncotarget, 2016-8
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128
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5 KB
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Multi-omic measurement of mutually exclusive loss-of-function enriches for candidate synthetic lethal gene pairs.
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BMC Genomics, 2016-1
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978
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33 KB
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Connectivity Homology Enables Inter-Species Network Models of Synthetic Lethality.
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PLoS Comput Biol, 2015-10
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1492
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50 KB
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Inferring synthetic lethal interactions from mutual exclusivity of genetic events in cancer.
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Biol Direct, 2015-10
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813
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32 KB
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Cancer type-dependent genetic interactions between cancer driver alterations indicate plasticity of epistasis across cell types.
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Mol Syst Biol, 2015-7
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51
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3 KB
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A negative genetic interaction map in isogenic cancer cell lines reveals cancer cell vulnerabilities.
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Mol Syst Biol, 2013-10
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204
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8 KB
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Identification of potential synthetic lethal genes to p53 using a computational biology approach.
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BMC Med Genomics, 2013-9
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93
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3 KB
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Identification of synthetic lethal pairs in biological systems through network information centrality.
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BMC Med Genomics, 2013-8
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109
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4 KB
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Mapping genetic interactions in human cancer cells with rnAi and multiparametric phenotyping.
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Nat Methods, 2013-5
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442
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19 KB
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Decoding directional genetic dependencies through orthogonal CRISPR/Cas screens.
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BMC Genomics, 2014-2
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139
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7 KB
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